Coagulative necrosis is a type of accidental cell death typically caused by ischemia or infarction.

In coagulative necrosis, the architectures of dead tissue are preserved for at least a couple of days.

It is believed that the injury denatures structural proteins as well as lysosomal enzymes, thus blocking the proteolysis of the damaged cells.

The lack of lysosomal enzymes allows it to maintain a “coagulated” morphology for some time. Like most types of necrosis, if enough viable cells are present around the affected area, regeneration will usually occur.